20 Antiphospholipid syndrome.pmd

نویسندگان

  • R. M. Maaroufi
  • R. Hamdi
  • N. Jmili
  • M. Ghorbal
  • F. Bel Hadj Hamida
  • T. Mahjoub
چکیده

1Higher Institute of Biotechnology, Monastir, Tunisia. 2Department of Ophthalmology, Farhat Hached University Hospital, Sousse, Tunisia. Haematology and Autoimmune Diseases Unit, Faculty of Pharmacy, University of Monastir, Tunisia. Received: 29/04/03; accepted: 23/12/03 ABSTRACT Antiphospholipid antibodies may play an important role in the pathogenesis of retinal vascular occlusions; therefore, we investigated the prevalence among 33 patients with retinal vein and artery occlusions and 80 controls. Prevalence was 33% and 5% respectively. Ophthalmic examination and fluorescein angiography showed that occlusions were due to ischaemic events. The 11 patients were diagnosed with antiphospholipid syndrome: 9 patients were treated successfully with laser photocoagulation and anticoagulant and anti-aggregant therapy. Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. Our results suggest a correlation between antiphospholipid syndrome and retinal vein occlusions; we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy.

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تاریخ انتشار 2005